Ibuprofen induced drug loaded polymeric micelles |
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| Authors: | Song Wei Tan Hong Jun Wang Ke Hua Tu Hong Liang Jiang Li Qun Wang MOE |
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| Institution: | MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China |
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| Abstract: | Three model drugs with different function groups were chosen to dialyze with dextran-graft-poly(N-isopropylacrylamide).Only ibuprofen could induce the formation of drug loaded micelles,which was confirmed with dynamic light scattering and transmission electron microscope.Hydrogen-bonding between the amide groups of poly(N-isopropylacrylamide) and the carboxyl groups of ibuprofen was driving force for the drug-loaded micelle.It was also found that the diameter of the ibuprofen-loaded micelles changed reversibly against temperature. |
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| Keywords: | Micelle Thermo-sensitive Drug Hydrogen-bonding Poly(N-isopropylacrylamide) |
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