Screening of Three Transition Metal‐Mediated Reactions Compatible with DNA‐Encoded Chemical Libraries |
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| Authors: | Nicholas Favalli Gabriele Bassi Tania Zanetti Jrg Scheuermann Dario Neri |
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| Institution: | Nicholas Favalli,Gabriele Bassi,Tania Zanetti,Jörg Scheuermann,Dario Neri |
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| Abstract: | The construction of DNA‐encoded chemical libraries (DECLs) crucially relies on the availability of chemical reactions, which are DNA‐compatible and which exhibit high conversion rates for a large number of diverse substrates. In this work, we present our optimization and validation procedures for three copper and palladium‐catalyzed reactions (Suzuki cross‐coupling, Sonogashira cross‐coupling, and copper(I)‐catalyzed alkyne‐azide cycloaddition (CuAAC)), which have been successfully used by our group for the construction of large encoded libraries. |
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| Keywords: | DNA-encoded chemical libraries Suzuki coupling Sonogashira coupling CuAAC reaction copper palladium DNA-compatible reaction |
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