Synthesis of 1-(2-aminoethyl)pyrazoles under phase-transfer catalysis |
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| Authors: | O. S. Attaryan A. O. Baltayan R. E. Sagatelyan K. Ts. Takmazyan |
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| Affiliation: | (1) Institute of Organic Chemistry, National Academy of Sciences of Armenia, ul. Zakariya Sarkavaga 167a, Erevan, 375091, Armenia;(2) State University of Engineering of Armenian Republic, Erevan, Armenia |
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| Abstract: | Alkylation of pyrazoles with 2-chloroethylamine was performed under conditions of phasetransfer catalysis. Depending on the substrate acidity, the electrophilic substitution process may be accompanied by dehydrochlorination of the alkylating agent, so that 6 equiv of 2-chloroethylamine should be used in the alkylation of 3,5-dimethylpyrazole. |
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