| 壳聚糖─海藻酸钠微囊对蛋白质控制释放的研究 |
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| 引用本文： | 舒晓正,朱康杰.壳聚糖─海藻酸钠微囊对蛋白质控制释放的研究[J].功能高分子学报,1999(4). |
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| 作者姓名： | 舒晓正 朱康杰 |
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| 作者单位： | 浙江大学高分子科学与工程系!浙江杭州310027 |
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| 基金项目： | 国家自然科学基金!资助项目（ 编号：59873019） |
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| 摘 要： | 采用乳化法制备了可注射用壳聚糖海藻酸钠微囊， 其粒径小于２００ μｍ ，且具有相对较窄的近似高斯分布。牛血清白蛋白作为模型药物在微囊中的包埋率可超过５０ ％ 。通过壳聚糖在海藻酸钠微囊表面的复合，牛血清白蛋白从微囊中的持续释放时间从几个小时延长到半个月以上。
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| 关 键 词： | 壳聚糖 海藻酸钠微囊 牛血清白蛋白 药物控制释放 |
Protein Controlled Release from Chitosan Sodium Alginate Microcapsules |
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| SHU Xiao zheng,ZHU Kang jie.Protein Controlled Release from Chitosan Sodium Alginate Microcapsules[J].Journal of Functional Polymers,1999(4). |
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| Authors: | SHU Xiao zheng ZHU Kang jie |
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| Abstract: | The chitosan sodium alginate microcapsules for injectable usage were prepared by emulsification method. The diameter of microcapsules is less than 200 micron and posses a relative narrow and normal gauss distribution. The loading efficiency of Bovine Serum Album(BSA) in microcapsules is more than 50%. By the coating with chitosan on the surface of sodium alginate microcapsules, the BSA release from microcapsules is extended from several hours to more than half a month. |
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| Keywords: | chitosan sodium alginate microcapsules BSA drug controlled release |
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