New pyridoacridine alkaloids from the purple morph of the ascidian Cystodytes dellechiajei |
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Authors: | Delphine BryBernard Banaigs Christophe LongNataly Bontemps |
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Institution: | a Laboratoire de Chimie des Biomolécules et de l’Environnement, University of Perpignan Via Domitia, 52 Avenue Paul Alduy, 66860 Perpignan Cedex, France b Institut de Recherche Pierre Fabre, UMS-2597-ISTMT, 3 rue des Satellites, 31400 Toulouse, France |
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Abstract: | Two new pyridoacridine alkaloids, 13-didemethylaminocycloshermilamine D (1) and demethyldeoxyamphimedine (2), were isolated from the purple chromotype of the Western Mediterranean ascidian Cystodytes dellechiajei. This morph also contained the known shermilamine B (3), kuanoniamine D (4), N-deacetylshermilamine B (5), N-deacetylkuanoniamine D (6), styelsamines C (7), and D (8). The structures of new compounds were elucidated on the basis of spectroscopic data. A hypothetic biosynthetic pathway from the tetracyclic styelsamine D (8) was proposed for both compounds 1 and 2 and their antimicrobial potential was evaluated. |
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Keywords: | Pyridoacridine Cystodytes dellechiajei Ascidian |
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