Synthesis of Functionalized (2-Thienylcarbonyl)thiazoles and 4-(2-Thienyl)pyridines by Reaction of (2-Thienylcarbonyl)thioacetanilides and their Enamine Derivatives |
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| Authors: | Krystyna?Bogdanowicz-Szwed mailto:bogdanow@chemia.uj.edu.pl" title=" bogdanow@chemia.uj.edu.pl" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Jacek?Grochowski,Ma?gorzata?Krasodomska,Pawe??Serda |
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| Affiliation: | (1) Department of Organic Chemistry, Jagiellonian University, Pl-30060 Kraków, Poland;(2) Regional Laboratory, Jagiellonian University, Pl-30060 Kraków, Poland |
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| Abstract: | ![]()
Summary. The condensation of two molecules of 2-(2-thienylcarbonyl)thioacetanilides catalyzed by piperidine yielded thiazole derivatives as confirmed by X-ray crystal structure analysis. The reaction of malononitrile with 3-morpholino-3-(2-thienyl)acrylic acid thioanilides furnished 6-amino-1-aryl-4-(2-thienyl)-1,2-dihydro-2-thioxopyridine-5-carbonitriles. A similar reaction of malononitrile with 3-morpholino-3-(2-thienyl)acrylic acid anilides provided 2-oxopyridine-5-carbonitriles. |
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| Keywords: | . Michael addition 4-(2-Thienyl)pyridine (2-Thienylcarbonyl)thioacetanilides Thiazole Crystal structure. |
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