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Studies on the synthesis of phorboxazole B: stereoselective synthesis of the C28-C46 segment |
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| Authors: | De Run Li Yong Qiang TuGuo-Qiang Lin Wei-Shan Zhou |
| Affiliation: | a Shanghai Institute of Organic Chemistry, 354 Fenglin Road, Shanghai 200032, PR China b Department of Chemistry and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China |
| Abstract: | A stereoselective synthesis of C28-C46 segment of phorboxazole B is described. Key features of the synthetic route involved the use of 1,3-asymmetric induction of Mukaiyama aldol reaction to construct the stereogenic center at C35, and the employment of metalated oxazole chemistry to prepare the ketal 6. |
| Keywords: | phorboxazole boldFont" >B synthesis Mukaiyama aldol reaction oxazole |
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