Enantioselective reactions of <em>tert</em>-butyl glycinate-benzophenone Schiff base catalyzed by chiral phase-transfer catalyst in aqueous media without any organic solvent期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

*Enantioselective reactions of tert-butyl glycinate-benzophenone Schiff base catalyzed by chiral phase-transfer catalyst in aqueous media without any organic solvent*

Authors:	Nobuyuki Mase

Affiliation:	Department of Molecular Science, Faculty of Engineering, Shizuoka University, 3-5-1 Johoku, Hamamatsu 432-8561, Japan

Abstract:	Chiral phase-transfer catalyzed enantioselective alkylations of tert-butyl glycinate-benzophenone Schiff base were investigated in aqueous media without any organic solvent. Reactions in aqueous media smoothly proceeded to give the desired product in higher yield than under standard liquid-liquid biphasic conditions. In aqueous media the formation of benzophenone, which was caused by in situ hydrolysis of Schiff base, was depressed.

Keywords:	Chiral phase-transfer catalyst Asymmetric synthesis Aqueous media
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