An efficient procedure for the synthesis of coumarin derivatives using TiCl4 as catalyst under solvent-free conditions |
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Authors: | Hassan Valizadeh Abbas Shockravi |
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Institution: | a Department of Chemistry, Faculty of Science, Azarbaydjan University of Tarbiat-Moallem, PO Box 53714-161, Tabriz, Iran b Faculty of Chemistry, Teacher Training University of Tehran, Tehran, Iran |
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Abstract: | The ability of titanium(IV) chloride as a catalyst to promote the Pechmann condensation reaction with a range of phenols and β-keto esters is described.The reaction was carried out by addition of TiCl4 to a mixture of the phenol and the β-keto ester with thorough stirring in the absence of a solvent and represents an improvement on the classical Pechmann conditions. The yields of coumarins obtained via this novel protocol were significantly higher than those using the conventional method and the reaction duration was reduced to a few minutes or even a few seconds. |
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Keywords: | Pechmann condensation Titanium(IV) chloride Coumarin Solvent-free system |
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