Direct synthesis of hetero-biaryl compounds containing an unprotected NH2 group via Suzuki-Miyaura reaction |
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| Authors: | Takahiro Itoh Toshiaki Mase |
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| Institution: | Process Research, Process R&D, Banyu Pharmaceutical Co. Ltd, 9-1, Kamimutsuna 3-Chome, Okazaki, Aichi 444-0858, Japan |
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| Abstract: | Hetero-biaryl compounds were prepared via the Suzuki-Miyaura coupling reaction of hetero-aryl moieties containing an unprotected NH2 group and arylboronic acids. D-t-BPF was found to be an efficient ligand for the cross-coupling of NH2-unprotected hetero-aryl chlorides with phenylboronic acid. |
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| Keywords: | Suzuki-Miyaura reaction Unprotected NH2 group D-t-BPF |
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