Synthesis of symmetric and dissymetric bisperfluoroalkanesulfonylimides and evaluation of their inhibition on bovine carbonic anhydrase

This study describes a synthesis of symmetric and dissymmetric bis(perfluoroalkane)‐sulfonyl]imides by the reaction of the sodium salt of perfluoroalkanesulfonamide R_FSO₂NH⁻Na⁺ (R_F = C₄F₉, C₆F₁₃, C₈F₁₇) with hexamethyldisilazane and perfluoroalkanesulfonylfluoride R_FSO₂F (R_F = C₄F₉, C₆F₁₃, C₈F₁₇). They are obtained, in two steps, in moderate overall yield. Moreover, this paper provides a study of their inhibition on bovine carbonic anhydrase. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:542–548, 2008; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20452