Behavioral effects of ketamine and toxic interactions with psychostimulants |
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Authors: | Tamaki Hayase Yoshiko Yamamoto Keiichi Yamamoto |
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Institution: | (1) Department of Legal Medicine, Kyoto University Graduate School of Medicine, Faculty of Medicine, Kyoto 606-8501, Japan;(2) Yamamoto Research Institute of Legal Medicine, Okazakitennou-cho, Sakyo-ku, Kyoto 606-8335, Japan |
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Abstract: | Background The anesthetic drug ketamine (KT) has been reported to be an abused drug and fatal cases have been observed in polydrug users.
In the present study, considering the possibility of KT-enhanced toxic effects of other drugs, and KT-induced promotion of
an overdose without making the subject aware of the danger due to the attenuation of several painful subjective symptoms,
the intraperitoneal (i.p.) KT-induced alterations in behaviors and toxic interactions with popular co-abused drugs, the psychostimulants
cocaine (COC) and methamphetamine (MA), were examined in ICR mice. |
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Keywords: | |
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