|
|||||
|
|
Catalyst-Free [3+2] Cycloaddition of Isoquinolinium/Pyridinium Ylides and Electron-Deficient Alkenes |
|
| Authors: | Xueting Zhou Jun Shi Jun-Rong Song Prof. Dr. Wei-Dong Pan Prof. Dr. Hai Ren Prof. Dr. Wei Wu |
| Affiliation: | State Key Laboratory of Functions, and Applications of Medicinal Plants, Guizhou Medical University, The Key laboratory of Chemistry for, Natural Products of Guizhou Province, and Chinese Academy of Science, Guiyang, 550014 P. R. China |
| Abstract: | The development of simple-to-operate methods for the preparation of indolizidine derivatives are of great importance. A mild one-pot protocol for the [3+2] cycloaddition of isoquinolinium/pyridinium ylides and electron-deficient alkenes using NaBH3CN as reductant has been developed. The protocol has a broad substrate scope (more than 40 examples) and provides various novel hexahydroindolizidine derivatives in high yields and excellent diastereoselectivities (up to >20/1). |
| Keywords: | catalyst-free [3+2] cycloaddition indolizidine pyrroloisoquinoline N-ylides |