Pd-Catalysed Diastereoselective Synthesis of aza-Spirocyclic P-Stereogenic Phosphine Oxides |
| |
| Authors: | Bin Zhang Prof Dr Xiao-Ming Zhang Prof Dr Qing-Wei Zhang |
| |
| Institution: | 1. Department of Chemistry, University of Science and Technology of China, 230026 Hedei, P. R. China;2. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 730000 Lanzhou, P. R. China |
| |
| Abstract: | Phosphine oxides and spirocyclic compounds are privileged molecules widely employed in a variety of catalytic transformations either as chiral ligands for metals or bifunctional organocatalysts. Herein, we developed a Pd-catalysed cross-coupling reaction to synthesize spirocyclic amino-phosphine oxides with a P-stereogenic centre which could serve as potential P*(O), N-ligands or organocatalysis. |
| |
| Keywords: | amino-phosphine ligand catalytic asymmetric diastereoselective spiro-ligands P-stereogenic |
|
|
