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Fluorinated Analogues to the Pentuloses of the Pentose Phosphate Pathway |
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| Authors: | Lukas Scheibelberger Toda Stankovic Kaja Liepert Andreas Kienzle Eva-Maria Patronas Dr Theresa Balber Prof?Dr Markus Mitterhauser Prof?Dr Arvand Haschemi Dr Katharina Pallitsch |
| Institution: | 1. Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090 Vienna, Austria
Vienna Doctoral School in Chemistry (DoSChem), University of Vienna, Währinger Straße 42, 1090 Vienna, Austria These authors contributed equally to this work.;2. Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090 Vienna, Austria These authors contributed equally to this work.;3. Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090 Vienna, Austria;4. Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Währinger Gürtel 18–20, 1090 Vienna, Austria;5. Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Währinger Gürtel 18–20, 1090 Vienna, Austria Ludwig Boltzmann Institute Applied Diagnostics, Währinger Gürtel 18–20, 1090 Vienna, Austria;6. Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Währinger Gürtel 18–20, 1090 Vienna, Austria Ludwig Boltzmann Institute Applied Diagnostics, Währinger Gürtel 18–20, 1090 Vienna, Austria Institute of Inorganic Chemistry, University of Vienna, Währinger Straße 42, 1090 Vienna, Austria;7. Department of Laboratory Medicine, Medical University of Vienna, Währinger Gürtel 18–20, 1090 Vienna, Austria |
| Abstract: | Fluorinated carbohydrates are valuable tools for enzymological studies due to their increased metabolic stability compared to their non-fluorinated analogues. Replacing different hydroxyl groups within the same monosaccharide by fluorine allows to influence a wide range of sugar–receptor interactions and enzymatic transformations. In the past, this principle was frequently used to study the metabolism of highly abundant carbohydrates, while the metabolic fate of rare sugars is still poorly studied. Rare sugars, however, are key intermediates of many metabolic routes, such as the pentose phosphate pathway (PPP). Here we present the design and purely chemical synthesis of a set of three deoxyfluorinated analogues of the rare sugars d -xylulose and d -ribulose: 1-deoxy-1-fluoro-d -ribulose ( 1DFRu ), 3-deoxy-3-fluoro-d -ribulose ( 3DFRu ) and 3-deoxy-3-fluoro-d -xylulose ( 3DFXu ). Together with a designed set of potential late-stage radio-fluorination precursors, they have the potential to become useful tools for studies on the complex equilibria of the non-oxidative PPP. |
| Keywords: | deoxyfluorinated carbohydrates d-Ribulose d-Xylulose pentose-phosphate-pathway rare sugars |