硝基苯并咪唑衍生物的合成、表征及抑菌活性的测定

以苯并咪唑为原料，经硝化、二茂铁磺酰化等步骤，合成了8种未见文献报道的硝基苯并咪唑衍生物,其结构经MS，¹H NMR和元素分析确证.由于硝基苯并咪唑的互变异构,二茂铁磺酰化后，产生两个异构体,用X射线衍射仪测定了化合物2a的晶体结构.初步的抑菌实验结果表明,该系列化合物具有良好的抑菌作用，其抑菌活性均优于对照药剂50%多菌灵可湿性粉剂.

Synthesis, Structure and Bioactivity of Nitrobenzoimidazole Derivatives

It was reported that benzoimidazole and ferrocene compounds maybe exhibit high pharmaceutical functions.Eight new nitrobenzoimidazole derivatives were prepared by the reaction of ferrocene sulfonylchloride with 5-nitrobenzoimidazole and characterized by means of elemental analysis,MS and ~(1)H NMR.The structure of the new compounds was further confirmed by X-ray crystallograghic analysis as exemplified by compounds 3b.The activities of compounds 3a-4d were evaluated against five fungicides.Compared with carbendazim(50% wet powder),better inhibitory activities were observed for these synthesized compounds.