Synthesis and pharmacological activity of 4-(4'-(chlorophenyl)-4-hydroxypiperidine) derivatives |
| |
Authors: | Saify Zafar Saeed Mushtaq Nousheen Khan Khalid Mohammed Perveen Shahnaz Shah Syed Tasadaque Ali Abdel-Jalil Raid Jamil Fecker Miriam Voelter Wolfgang |
| |
Institution: | HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi, Pakistan. hassaan2@super.net.pk |
| |
Abstract: | A new series of 4-(4'-chlorophenyl)-4-hydroxypiperidine derivatives (2-5), substituted at nitrogen, were synthesized and tested as potential analgesic compounds as well as evaluated for their effect on hypotensive activity. Results showed that all the derivatives exhibit significant analgesic activity in male Wistar rats at a dose of 50 mg/kg of body weight after intramuscular injection, when tested by thermal stimuli (tail flick test). Pethidine was used as reference drug. Compounds 2, 3 and 5 produced reduction in blood pressure in normotensive rat. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|