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Synthesis, crystal structures, electrochemical studies and anti-tumor activities of three polynuclear organotin(IV) carboxylates containing ferrocenyl moiety |
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| Authors: | Mei-Lan Sun Ban-Feng Ruan Qiong Zhang Sheng-Li Li Bao-Kang Jin Sheng-Yi Zhang |
| Affiliation: | a Department of Chemistry, Anhui Province Key Laboratory of Functional Inorganic Material Chemistry, Anhui University, Hefei 230039, PR China b School of Medical Engineering, Hefei University of Technology, Hefei 230009, PR China c State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, PR China d State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 250100, PR China |
| Abstract: | A novel ferrocene-containing ligand 3-trifluoromethyl-5-ferrocenyl -pyrazol-1-yl-acetic acid (LCOOH) and three organotin(IV) carboxylate derivatives [Ph4Sn2O(OCH3)(OOCL)]2(1), [BuSnO(OOCL)]6(2) and [Bu4Sn2O(OOCL2)2] (3) have been synthesized and structurally characterized by means of FT-IR, elemental analysis, 1H NMR, 119Sn NMR, X-ray crystallography and cyclic voltammetry. Both complexes 1 and 3 are centrosymmetric with ladder framework. Complex 2 is a hexanuclear one with drum structure. Furthermore, their anti-tumor activities were also evaluated, using HepG2 human hepatocellular liver carcinoma cells, A549 human lung carcinoma cells and B16-F10 melanoma cells. Complex 1 displayed the best cytotoxicity and can be pointed out as a promising substrate to be subject of further investigations. |
| Keywords: | Ferrocene Organotin(IV) complex Single crystal structure Antitumor activitiy |
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