Synthesis of 3-methyl-2-cyclohexenones catalyzed by mercury(II) salts and their microwave assisted BiCl3 catalyzed aldol condensations |
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| Authors: | Chen Zhang Bi-Song Wang Shao-Qiao Zhang |
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| Institution: | a College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, PR China
b College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China |
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| Abstract: | HgSO4 catalyzed hydrative cyclization of 1,6-heptadiynes is present. This reaction proceeded smoothly under the mild condition for differently 4-sustituted 1,6-diynic substrates giving corresponding 3-methyl-2-cyclohexenones with high to excellent yield. The microwave assisted aldol condensation of cyclohexenones under the catalysis of BiCl3 afforded 3-styryl-cyclohexenones with high regio- and stereo-selectivity. |
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| Keywords: | 3-Methyl-2-cyclohexenones Mercury(II) salts BiCl3 Microwave Lewis acid Aldol condensation |
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