Microwave-assisted synthesis of some novel fluorinated pyrazolo[3,4-d]pyrimidine derivatives containing 1,3,4-thiadiazole as potential antitumor agents |
| |
| Authors: | Xin Jian Song Yu Shao Xing Gao Dong |
| |
| Affiliation: | a Key Laboratory of Biological Resources Protection and Utilization of Hubei Province, Hubei University for Nationalities, Enshi 445000, China;b Medical School, Hubei University for Nationalities, Enshi 445000, China |
| |
| Abstract: | ![]()
A facile microwave-assisted procedure for synthesis of novel fluorinated pyrazolo[3, 4-d]pyrimidine derivatives containing 1, 3, 4-thiadiazole is described. This protocol presented such advantages as short reaction time, high yields, simple purification and environmentally benign procedures. Their antitumor activities were evaluated against HL-60 by an MTT assay. The preliminary results indicated that some title compounds exhibit more potent antitumor inhibitory activity than doxorubicin (DOX). |
| |
| Keywords: | Pyrazolo[3 4-d]pyrimidine 1 3 4-Thiadiazole Microwave-assisted synthesis Antitumor activity |
|
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
|
点击此处可从《中国化学快报》下载全文 |
|
