Blood Coagulation and Living Tissue Sterilization by Floating-Electrode Dielectric Barrier Discharge in Air |
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| Authors: | Gregory Fridman Marie Peddinghaus Manjula Balasubramanian Halim Ayan Alexander Fridman Alexander Gutsol Ari Brooks |
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| Institution: | (1) School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA;(2) Pathology and Laboratory Medicine Department, College of Medicine, Drexel University, 245 N. 15th Street MS #413, Philadelphia, PA 19102, USA;(3) Department of Mechanical Engineering and Mechanics, College of Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA;(4) Department of Surgery, College of Medicine, Drexel University, 245 N. 15th Street MS #413, Philadelphia, PA 19102, USA;(5) Department of Electrical and Computer Engineering, College of Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA |
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| Abstract: | Thermal plasma discharges have been widely used in the past for treatment of living human and animal tissue. However, extensive thermal damage and tissue desiccation occurs due to extreme temperatures. Some solutions have been offered where the temperature is lowered by short current pulses, addition of noble gases, or significant decrease in the size of treatment electrodes. We propose a method of direct treatment of living tissue that occurs at room temperature and pressure without visible or microscopic tissue damage. The presented Floating-Electrode Dielectric Barrier Discharge plasma is proven electrically safe to human subjects and our results show no gross (visual) or histological (microscopic) damage to skin samples in minutes, complete tissue sterilization from skin flora in seconds, and blood clot formation in seconds of electric plasma treatment. We also observe significant hastening of blood clot formation via electric plasma induced catalysis of “natural” processes occurring in human blood. A model describing these processes is offered.An erratum to this article can be found at |
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| Keywords: | Non-thermal plasma Sterilization Disinfection Blood coagulation Blood coagulation model Blood clotting Wound healing |
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