| Abstract: | Differential proteins expressing in ectopic and eutopic endometria were investigated by means of proteomic analysis.Five patients in secretary phase were diagnosed as endometriosis by laparoscopy.The five ectopic en-dometria(two at stage II,two at stage III and one at stage IV) and five eutopic endometria were surgically excised.One-dimensional electrophoresis coupled with liquid chromatography and mass spectrometry was used to screen and identify differential proteins.Three differential bands in one-dimensional electrophoresis were resolved by liquid chromatography and mass spectrometry and 14 up-regulated proteins were identified,including collagen α-1,α-2,α-3(VI),α-1(XIV) chain,actin,annexin A2,EMILIN-1,ferritin light polypeptide variant,fucosyltransferase 10,myosin-9,protein S100-A9,KIAA1783 protein,and two hypothetical proteins.Our data provides a list of potential biomarkers for endometriosis.The identifications may be used to develop new diagnoses for endometriosis. |
