Myrothecoside,a Novel Glycosylated Polyketide from the Terrestrial Fungus Myrothecium sp. GS‐17 |
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| Authors: | Songya Zhang Jing Zhu Tao Liu Suzan Samra Huaqi Pan Jiao Bai Huiming Hua Andreas Bechthold |
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| Institution: | 1. Institut für pharmazeutische Biologie und Biotechnologie, Albert‐Ludwigs Universit?t, Freiburg, Germany;2. Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang, P. R. China;3. Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, P. R. China;4. Key Laboratory of Structure‐Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, P. R. China;5. +49‐761‐2038371 |
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| Abstract: | Based on the chemical analysis and targeted bioactivity screening, a new polyketide glycoside, myrothecoside, was isolated from a terrestrial halotolerant fungus, Myrothecium sp. GS‐17. The structure of myrothecoside was elucidated on the basis of extensive spectroscopic analysis including 1D‐ and 2D‐NMR (1H,1H‐COSY, HSQC, HMBC, and NOESY) experiments, combined with mass spectroscopic data and physicochemical properties. This compound exhibited weak cytotoxicity against human leukemia (HL‐60) cancer cell with an IG50 value of 63.61 μm , and also antifungal activities against plant pathogenic fungi Rhizoctonia solani and Fusarium oxysporum using standard agar diffusion tests at 20 μg/disk. |
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| Keywords: | Secondary metabolites Fungi
Myrothecium
Glycosylated polyketides Antibacterial activity |
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