Synthesis of Novel Isoindolo[2,1‐a]quinazolinedione Derivatives Containing a 1,2,3‐Triazole Ring System |
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| Authors: | Fatemeh Esmaeili‐Marandi Mina Saeedi Issa Yavari Mohammad Mahdavi Abbas Shafiee |
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| Affiliation: | 1. Department of Chemistry, College of Basic Science, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran;2. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;3. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran;4. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran (fax: +98‐21‐66461178) |
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| Abstract: | A synthesis of isoindolo[2,1‐a]quinazolinedione derivatives, coupled with a 1,2,3‐triazole ring system, via the reaction of isatoic anhydride, HC?CCH2NH2, and 2‐formylbenzoic acid is described, which led to the formation of the isoindolo[2,1‐a]quinazoline‐5,11‐dione scaffold having a C?C bond that participated in a click reaction with various organic azides. |
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| Keywords: | Click reaction Isoindolo[2,1‐a]quinazolinediones Isatoic anhydride Propargylamine 1,2,3‐Triazoles |
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