| Synthesis of Fragment Derivatives of Delta Sleep-inducing Peptide （1-4） Catalyzed by Enzymes in Organic Solvents |
| |
| 引用本文： | 沈鸿雁,田桂玲,洪毅颖,李恒,叶蕴华.Synthesis of Fragment Derivatives of Delta Sleep-inducing Peptide （1-4） Catalyzed by Enzymes in Organic Solvents[J].中国化学,2005,23(5):640-642. |
| |
| 作者姓名： | 沈鸿雁 田桂玲 洪毅颖 李恒 叶蕴华 |
| |
| 作者单位： | KeyLaboratoryofBioorganicChemistryandMolecularEngineering,MinistryofEducation,CollegeofChemistryandMolecularEngineering,PekingUniversity,Beifing100871,China |
| |
| 摘 要： | Synthesis of two fragment derivatives of delta sleep-inducing peptide (DSIP) (1-4), Boc-Trp-Ala-Gly-GlyNHNHPh (1) and Boc-Trp-Ala-Gly-GlyOEt (2), catalyzed by proteases via 2 2 or 1 3 synthetic routes with different protecting groups at C-terminal in organic solvents was reported. The yield of N-Boc tetrapeptide with phenylhydrazinyl protecting carboxyl group at C-terminal (1) was higher than that of N-Boc tetrapeptide ethyl ester (2) by 2 2 route. The factors influencing the synthetic yield of the fragments of DSIP (1-4) were discussed.
|
| 关 键 词： | 缩氨酸 有机溶剂 酶 合成方法 生物活性 |
Synthesis of Fragment Derivatives of Delta Sleep‐inducing Peptide (1‐4) Catalyzed by Enzymes in Organic Solvents |
| |
| Shen Hong‐Yan,Tian Gui‐Ling,Hong Yi‐Ying,Li Heng,Ye Yun‐Hua.Synthesis of Fragment Derivatives of Delta Sleep‐inducing Peptide (1‐4) Catalyzed by Enzymes in Organic Solvents[J].Chinese Journal of Chemistry,2005,23(5):640-642. |
| |
| Authors: | Shen Hong‐Yan Tian Gui‐Ling Hong Yi‐Ying Li Heng Ye Yun‐Hua |
| |
| Abstract: | Synthesis of two fragment derivatives of delta sleep‐inducing peptide (DSIP) (1‐4), Boc‐Trp‐Ala‐Gly‐GlyNH‐NHPh ( 1 ) and Boc‐Trp‐Ala‐Gly‐GlyOEt ( 2 ), catalyzed by proteases via 2+2 or 1+3 synthetic routes with different protecting groups at C‐terminal in organic solvents was reported. The yield of N‐Boc tetrapeptide with phenylhy‐drazinyl protecting carboxyl group at C‐terminal ( 1 ) was higher than that of N‐Boc tetrapeptide ethyl ester ( 2 ) by2+2 route. The factors influencing the synthetic yield of the fragments of DSIP (1‐4) were discussed. |
| |
| Keywords: | DSIP enzymatic synthesis organic solvent peptide |
| 本文献已被 维普 等数据库收录！ |
