| 用外推容量因子法测定药物的疏水性 |
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| 引用本文： | 樊淑彦,蒋晔.用外推容量因子法测定药物的疏水性[J].分析化学,1992,20(4):437-439. |
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| 作者姓名： | 樊淑彦 蒋晔 |
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| 作者单位： | 河北医学院药学系分析化学教研室，河北医学院药学系分析化学教研室，河北医学院药学系分析化学教研室 石家庄 050017，石家庄 050017，石家庄 050017 |
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| 摘 要： | 本文利用不同体积分数的甲醇-水作流动相,用外推容量因子法测定20种不同结构类型药物的疏水性,该法操作简便、快速、测定疏水性范围宽,相关性好。
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| 关 键 词： | 外推容量因子 疏水性 药物 |
Determination Hydrophobicity of Drugs by Extrapolated Capacity Factor Method |
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| Fan Shuyan,Jiang Ye,Wang Yunzhi.Determination Hydrophobicity of Drugs by Extrapolated Capacity Factor Method[J].Chinese Journal of Analytical Chemistry,1992,20(4):437-439. |
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| Authors: | Fan Shuyan Jiang Ye Wang Yunzhi |
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| Abstract: | Hydrophobicity of twenty non-congeneric drugs was determined by extrapolated capacity factor method using varying volume fractions of methanol-water as eluents. The method was simple and rapid to operate, the range for the determination of hydrophobicity was 4.88>log Pow>-1.22, in which Pow is octanol-water partition coefficient, the correlation between logKw and logPow was good. |
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| Keywords: | Hydrophobicity Extrapolated capacity factor Quantitative structure activity relationship Octanol-water partition coefficient |
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