Pyrogallic acid‐PLGA conjugate as new biodegradable material suitable for final sterilization by irradiation |
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Authors: | Francesco Cilurzo Francesco Puoci Francesca Selmin Francesca Iemma Paola Minghetti |
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Institution: | 1. Department of Pharmaceutical Sciences “P. Pratesi”, Università degli Studi di Milano, via G. Colombo 71, 20133 Milan, Italy;2. Pharmaceutical Sciences Department, University of Calabria, Edificio Polifunzionale, 87039 Arcavacata di Rende (CS), Italy |
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Abstract: | This paper reports the feasibility to prepare a biodegradable material stable to γ‐irradiation by grafting of poly(lactide‐co‐glycolide) with pyrogallic acid (PLGA‐g‐PA) and ferulic acid (PLGA‐g‐FA) in mild condition. Only the grafting procedure with PA did not modify molecular weight (Mw) of the starting polymer and PLGA‐g‐PA showed antioxidant properties. The polymer degradation in pH 7.4 phosphate buffer saline (PBS) was mainly governed by a random chain scission mechanism according to a first‐order reaction. The irradiation at the dose of 25 kGy caused only a very slight decrease of Mw and the degradation patterns of the non‐irradiated and irradiated material were superimposable. PLGA‐g‐PA resulted a promising material to develop biodegradable drug delivery systems which would be sterilizable in the final container. Copyright © 2010 John Wiley & Sons, Ltd. |
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Keywords: | γ ‐irradiation grafting poly(lactide‐co‐glycolide) pyrogallic acid |
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