Nanofibrosis of uncrystallizable poly(lactide‐co‐glycolide) via phase separation |
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| Authors: | Xiao Ping Yang Xiao Li Li Lei Zhang Qiao Fu Yang Qing Cai Xu Liang Deng |
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| Institution: | 1. The Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer, Beijing University of Chemical Technology, Beijing 100029, China;2. China School and Hospital of Stomatology, Peking University, Beijing 100081, China |
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| Abstract: | Poly(lactide‐co‐glycolide) (PLGA) copolymers are a kind of biocompatible and biodegradable materials being widely used in tissue engineering. However, phase separation had not been reported successfully in fabricating these amorphous polymers into nanofibrous matrix, although this technique had shown advantages over electrospinning in producing a nanofiber network. In this study, tetrahydrofuran (THF)/H2O solvent pairs were found suitable solvents to induce the formation of uniform PLGA gel at selected gelation temperatures. The results indicated that fine nanofibrous structures with fiber diameter around 40–60 nm could be obtained following the steps of gel formation, solvent extraction, and freeze‐drying, by controlling the concentration of PLGA/THF/H2O solution, THF/H2O ratio, and gelation temperature. Copyright © 2009 John Wiley & Sons, Ltd. |
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| Keywords: | poly(lactide‐co‐glycolide) nanofibrous phase separation |
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