Detection of sonoluminescence signals in a gel phantom in the presence of Protoporphyrin IX conjugated to gold nanoparticles |
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| Affiliation: | 1. Research Center and Department of Medical Physics, School of Medicine, Mashhad University of Medical Sciences, Vakil Abad Blvd., Mashhad, Iran;2. Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Darvaze Shiraz Blvd., Isfahan, Iran;3. Department of Chemistry, School of Science, Ferdowsi University of Mashhad, Vakil Abad Blvd., Mashhad, Iran;4. Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Vakil Abad Blvd., Mashhad, Iran;5. Department of Community Medicine & Public Health, School of Health, Mashhad University of Medical Sciences, Vakil Abad Blvd., Mashhad, Iran;6. Department of Electronic Engineering, School of Engineering, Isfahan University, Darvaze Shiraz Blvd., Isfahan, Iran;1. Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;2. Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;3. Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;1. Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, Ministry of Education, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi, China;2. School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China;3. Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China;1. Nano-Biophysics Lab, Department of Physics, University of Texas at Arlington, Arlington, TX 76019, USA;2. Joint Biomedical Engineering Program, University of Texas at Arlington, Arlington, TX 76019, USA;3. University of Texas Southwestern Medical Center, Dallas, TX 75235, USA;1. Division of Surgery and Interventional Sci., University College London, Royal Free Hospital, Pond St., London NW3 2PF, UK;2. Biomedical Sciences Research Institute, University of Ulster, Cromore Rd., Coleraine, Co. Derry BT52 1SA, UK;1. Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;2. Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;3. Department of Radiology Technology, Behbahan Faculty of Medical Sciences, Behbahan, Iran |
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| Abstract: | ![]()
The particles in a liquid decrease the ultrasonic intensity threshold required for cavitation onset. In this study, a new nanoconjugate composed of Protoporphyrin IX and gold nanoparticles (Au–PpIX) was used as a nucleation site for cavitation. The nonradiative relaxation time of Protoporphyrin IX in the presence of gold nanoparticles is longer than the similar time without gold nanoparticles. The acoustic cavitation activity was investigated via recording of the integrated sonoluminescence signal in the wavelength range of 220–700 nm in a gel phantom by a cooled charge coupled device (CCD) at different intensities of 1 MHz ultrasound. In order to confirm these results, a chemical dosimetric method was utilized, too. The recorded sonoluminescence signal in the gel phantom containing Au–PpIX was higher than the other phantoms. These records have been confirmed by the chemical dosimetric data. Therefore, we anticipate that a new nanoconjugate composed of Protoporphyrin IX and gold nanoparticles can act as an efficient sonoluminescence agent and could be introduced as a novel sonosensitizer for sonodynamic therapy. |
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