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Direct conversion of N-methoxy-N-methylamides (Weinreb amides) to ketones via a nonclassical Wittig reaction |
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| Authors: | Murphy John A Commeureuc Aurélien G J Snaddon Thomas N McGuire Thomas M Khan Tanweer A Hisler Kevin Dewis Mark L Carling Robert |
| Institution: | Department of Pure and Applied Chemistry, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow G1 1XL, UK. john.murphy@strath.ac.uk |
| Abstract: | reaction: see text] N-Methoxy-N-methylamides (Weinreb amides) are converted efficiently into ketones by reaction with alkylidenetriphenylphosphoranes and in situ hydrolysis of the product. |
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