Klick‐Chemie. Synthesen,die gelingen

Click‐Chemistry is a concept in organic synthesis that uses a limited amount of very reliable reactions on a broad variety of substrates. This leads within a few steps to molecules of high diversity which is important to accelerate drug‐discovery. Besides favourable thermodynamic requirements, the criteria for a click‐reaction include also simple reaction conditions and a quick and easy (almost unnecessary) workup. The most successful of these click‐reactions is the copper catalysed 1, 3‐dipolar cycloaddition of azides and alkynes, which in the meantime is used in most diverse areas of chemistry. The mechanistic ideas of this reaction is looked at in more detail.