Preparation and properties of redox responsive modified hyaluronic acid hydrogels for drug release |
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Authors: | Renyi Zhang Xian Li Kewen He Xueying Sheng Shuang Deng Yueqin Shen Guanjun Chang Xu Ye |
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Institution: | School of Materials Science and Engineering, Southwest University of Science and Technology, Mianyang, China |
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Abstract: | A series of oxidized hyaluronic acid (oxi‐HA)/3,3′‐dithiobis (propionohydrazide) (DTP) redox responsive hydrogels by Schiff base reaction under physiological conditions were designed and prepared. The influence of the concentration of oxi‐HA and DTP on rheological properties, equilibrium swelling ratio, and degradation rate were investigated. All oxi‐HA/DTP hydrogels exhibited good rheological properties, high equilibrium swelling ratio, low degradation rate, and sustainable drug release properties, and the comprehensive performance of oxi‐HA5/DTP6 hydrogel was better than that of others. The redox responsiveness was evaluated by means of degradation and in vitro bovine serum albumin release behavior investigation with the stimulus of different concentration of dithiothreitol as reducing agent. The intelligent hydrogels could be potentially applied in the fields of drug delivery system, tissue engineering, or cell scaffold materials. Copyright © 2017 John Wiley & Sons, Ltd. |
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Keywords: | hydrogels redox responsive hyaluronic acid drug release |
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