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Iron(III)‐Selective Chelation‐Enhanced Fluorescence Sensing for In Vivo Imaging Applications |
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| Authors: | Lin E. Guo Xin Yi Liu Huan Wang Qiu Ling Chen Guang Ke Wang Prof. Kaijun Luo Qi Li Mi Prof. Ying Zhou Jun Feng Zhang |
| Affiliation: | 1. College of Chemical Science and Technology, Yunnan University, Kunming, China;2. College of Life Science, Yunnan University, Kunming, China;3. College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, China;4. Yunnan Institute of Microbiology, Yunnan University, Kunming, China;5. Technology Center, China Tobacco Yunnan Industrial Co., Ltd, Kunming, China |
| Abstract: | A “turn‐on” pattern Fe3+‐selective fluorescent sensor was synthesized and characterized that showed high fluorescence discrimination of Fe3+ over Fe2+ and other tested ions. With a 62‐fold fluorescence enhancement towards Fe3+, the probe was employed to detect Fe3+ in vivo in HeLa cells and Caenorhabditis elegans, and it was also successfully used to elucidate Fe3+ enrichment and exchange infected by innexin3 (Inx3) in hemichannel‐closed Sf9 cells. |
| Keywords: | dyes/pigments fluorescence fluorescent probes iron sensors |