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Two new 19-oxygenated ent-kaurane diterpenoids from Isodon pharicus
Authors:Yong Zhao  Jian Xin Pu  Sheng Xiong Huang  Li Bin Yang  Wei Lie Xiao  Li Mei Li  Li Sheng Ding  Han Dong Sun
Institution:a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China;b College of Chemistry and Engineering, Yunnan Normal University, Kunming 650092, China;c Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
Abstract:Two new 19-oxygenated ent-kaurane diterpenoids,pharicinins D and E(1 and 2),together with an artifact,pharicinin D acetal (3) were isolated from the leaves of Isodon pharicus.Their structures were determined by 1D and 2D NMR spectroscopic analysis. All of them were evaluated for their cytotoxicity.
Keywords:Isodon pharicus  Labiatae  ent-Kaurane diterpenoid  
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