Synthesis of antidepressant duloxetine via asymmetric transfer hydrogenation |
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| Authors: | Shan Zhen He Xue Ming Li Jia Dai Ming Yan |
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| Affiliation: | a The Industrial Institute of Fine Chemicals and Synthetic Drugs, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510080, China;b Guangdong Provincial People's Hospital, Guangzhou 510060, China |
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| Abstract: | ![]()
Antidepressant duloxetine (1) was prepared via asymmetric transfer hydrogenation of 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one (3). The Ru(Ⅱ), Rh(Ⅲ) and Ir(Ⅲ) complexes of several chiral ligands were examined as the catalyst and(S,S)-N-tosyl-1,2-diphenyl ethylenediamine (TsDPEN)-Ru(Ⅱ) complex was found to provide good yield and excellent enantios-electivity. |
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| Keywords: | Duloxetine Synthesis Asymmetric transfer hydrogenation |
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