| 铂类抗癌药物-纳米金载药体系的研究进展 |
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| 引用本文： | 刘清华,杨萍,高传柱,杨波,钱韵旭.铂类抗癌药物-纳米金载药体系的研究进展[J].化学通报,2017,80(11):995-1001. |
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| 作者姓名： | 刘清华 杨萍 高传柱 杨波 钱韵旭 |
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| 作者单位： | 昆明理工大学生命科学与技术学院,昆明理工大学生命科学与技术学院,昆明理工大学生命科学与技术学院,昆明理工大学生命科学与技术学院,昆明理工大学生命科学与技术学院 |
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| 摘 要： | 铂类抗癌药物凭借着独特的作用机制,已成为临床治疗中应用广泛的抗癌药物之一。但由于存在较为严重的毒副作用、耐药性等问题,限制了其在临床上的使用。为了改善它的这些不足,更大限度提高药物的生物利用度并尽量减少其副作用,使用靶向给药体系改变铂类药物体内递送方式受到了广泛关注。其中铂药-纳米金载药体系因其较大的载药量、易于修饰改造、癌细胞高通透性和滞留效应、无免疫原性等显著的特点而受到研究者们的重视,本文主要介绍近十年来铂类抗癌药物-纳米金载药体系的研究进展。
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| 关 键 词： | 铂类药物 金纳米 载药体系 |
| 收稿时间： | 2017/4/12 0:00:00 |
| 修稿时间： | 2017/6/28 0:00:00 |
Research progresses on gold nanoparticle-based delivery systems of antitumor platinum drugs |
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| Liu Qinghu,Yang Ping,Gao Cshuanzhu,Yang Bo and Qian Yunxu.Research progresses on gold nanoparticle-based delivery systems of antitumor platinum drugs[J].Chemistry,2017,80(11):995-1001. |
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| Authors: | Liu Qinghu Yang Ping Gao Cshuanzhu Yang Bo and Qian Yunxu |
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| Institution: | Faculty of Life Science and Technology,Kunming University of Science and Technology,Faculty of Life Science and Technology,Kunming University of Science and Technology,Faculty of Life Science and Technology,Kunming University of Science and Technology,Faculty of Life Science and Technology,Kunming University of Science and Technology,Faculty of Life Science and Technology,Kunming University of Science and Technology |
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| Abstract: | Platinum drugs have become one of the most widely used anticancer drugs for their unique mechanisms of action. However, platinum anticancer drugs were limited by serious side effects, drug resistance and other issues. In order to overome the deficiencies of platinum anticancer drugs, improve the bioavailability of platinum anticancer drugs and reduce their side effects, targeted drug delivery system to change the in vivo?transmission?method, the platinum drugs has been widely concerned. Among of them, the platinum drugs-gold nanoparticles delivery system has significantly caused the attention of researchers for its high loading capacity, easy modification, cancer cells EPR effect and non-immunogenicity, etc. In this paper, research progress on nanogold delivery systems for platinum-based antitumor drugs has been introduced in recent ten years. |
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| Keywords: | platinum drugs gold nanoparticles drug loading system |
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