| 含双-三唑并噻二唑环的庚烷类衍生物的合成及抗菌活性 |
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| 引用本文： | 李永双,李德江.含双-三唑并噻二唑环的庚烷类衍生物的合成及抗菌活性[J].化学研究与应用,2009,21(7). |
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| 作者姓名： | 李永双 李德江 |
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| 作者单位： | 三峡大学,化学与生命科学学院,湖北,宜昌,443002 |
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| 基金项目： | 湖北省教育厅科学技术重点研究项目 |
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| 摘 要： | The aroylhydrazides were prepared by esterification and hydrazinolysis of corresponding aromatic carboxylic acids.The reaction of aroylhydrazides with CS2/KOH in absolute ethanol gave potassium aroyldithiocarbazates and then hydrazinolysis of potassium aroyldithiocarbazates with hydrazine hydrate afforded 3-aryl-4-amino-5-mercapto-1,2,4-triazoles(1a～1g).New seven compounds of bis(3-aryl)-s-triazolo3,4-b]-1,3,4]thiadiazole derivatives(2a～2g) were synthesized in high yields by cyclization of nonanedioic ac...
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| 关 键 词： | 1 2 4-三氮唑 双-1 2 4-三唑并[3 4 b]-1 3 4-噻二唑 合成 抑菌活性 |
Synthesis and antibacterial activities of heptanes derivatives containing bis-triazolo[3,4-b]-[1,3,4]thiadiazole |
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| LI Yong-shuang,LI De-jiang.Synthesis and antibacterial activities of heptanes derivatives containing bis-triazolo[3,4-b]-[1,3,4]thiadiazole[J].Chemical Research and Application,2009,21(7). |
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| Authors: | LI Yong-shuang LI De-jiang |
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| Institution: | College of Chemistry and Life Science;China Three Gorges University;Yichang 443002;China |
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| Abstract: | The aroylhydrazides were prepared by esterification and hydrazinolysis of corresponding aromatic carboxylic acids.The reaction of aroylhydrazides with CS2/KOH in absolute ethanol gave potassium aroyldithiocarbazates and then hydrazinolysis of potassium aroyldithiocarbazates with hydrazine hydrate afforded 3-aryl-4-amino-5-mercapto-1,2,4-triazoles (1a～1g).New seven compounds of bis(3-aryl)-s-triazolo3,4-b]-1,3,4]thiadiazole derivatives (2a～2g) were synthesized in high yields by cyclization of nonanedioic acid with 3-aryl-4-amino-5- mercapto-1,2,4-triazoles (1a～1g).The structures of 2a～2g were confirmed by elementary analyses,IR,1H NMR,and MS spectra.The preliminary antibacterial tests showed that most of them had good antibacterial activities. |
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| Keywords: | 1 2 4-triazole bis[(3-aryl)-1 2 4-triazolo[3 4-b]-[1 3 4]thiadiazole synthesis antibacterial activities |
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