Structures of americanol A and isoamericanol A having a neurotrophic property from the seeds of Phytolacca americana. |
| |
| Authors: | Y Fukuyama T Hasegawa M Toda M Kodama H Okazaki |
| |
| Institution: | Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan. |
| |
| Abstract: | The structures of new neo-lignans, isoamericanol A (1) and americanol A (2) isolated from the seeds of Phytolacca americana have been elucidated on the basis of spectroscopic data and then confirmed by chemical correlation with the previously known isoamericanin A (3) and americanin A (4). Isoamericanol A, americanol A, and americanin A have been found to enhance choline acetyltransferase activity at 10(-5) M in a cultured neuronal cell system derived from fetal rat hemisphere. |
| |
| Keywords: | |
|
|
