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Apoptosis mediated by caspase-3 and p53-dependent anticancer effects of 159Gd-DTPA-BMA complex |
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| Authors: | Daniel Crístian Ferreira Soares André Luís Branco de Barros Raquel Gouvêa dos Santos Edésia Martins Barros de Sousa Gilson Andrade Ramaldes |
| Institution: | 1. Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Presidente Ant?nio Carlos, 6627-Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil 2. Centro de Desenvolvimento da Tecnologia Nuclear-Comiss?o Nacional de Energia Nuclear, Avenida Presidente Ant?nio Carlos, 6627-Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil |
| Abstract: | In this work the apoptosis mediated by caspase-3 and p53-dependent anticancer effects of 159Gd-DTPA-BMA metal complex were evaluated against RT2 glioblastoma cells. The results showed that the mechanism of cell death involves apoptosis by caspase-3 activation. Furthermore, the involvement of p53 protein triggered by 159Gd-DTPA-BMA in these cells was verified preliminarily. Considering these finding, the radioactive complex can be considered as potential therapeutic alternative agent against cancer. |
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