8,2'-O-环化-9β-D-腺嘌呤阿拉伯糖苷的NMR及结构研究

8,2'-O-环化-9β-D-腺呤阿拉伯糖苷是阿糖腺苷合成过程中的一个关键性中间体,该化合物的NMR数据只有¹H-NMR谱的糖环1'位质子化学位移和偶合常数的报道,¹³C-NMR谱未曾报道。本文用2D-NMR、NOE-DIF等技术,对它的¹H、¹³C-NMR谱进行归属,进一步明确了它的结构。

STUDY ON NMR AND STRUCTURE OF 8, 2'-O-CYCLO-ARA-A

8, 2 '- o - cyclo-Ara-A is the key intermediate for the synthesis of Ara -A. There is a few reports on the NMR of this compound, only H -1 ' chemical shifts and coupling constants were reported, but no ~(13)C-NMR data reported. ~1H and ~(13)C NMR spectra of 8, 2 '-o -cyclo- Ara- A were assigned by ~1H-~1H COSY, ~(13)C-~1H COSY and NOE-DIFFERENCE techniques. The conformation of sugar ring was further confirmed.