Influence of laser power density on damage of comb by photodynamic therapy—simulation and validation of mathematical models

Photodynamic therapy （PDT） has poor therapeutic outcomes for the treatment of port-wine stain （PWS） lesions with long drug-light intervals （DLIs）. This letter investigates the possibility of improving the treatment efficacy through increasing the laser power density using a computer simulation and a cock comb model. The computational model includes a Monte Carlo simulation for the laser distribution and a calculation of the singlet oxygen concentrations （102）. Both simulation and experimental results show that increasing the power density from i00 to 140 mW/cm^2 not only improves the PDT efficacy, but also results in the unwanted skin damage.