Analysis of solute diffusion in poly(vinyl alcohol) hydrogel membrane |
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| Affiliation: | 1. Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada;2. Division of Endocrinology, University of Toronto, Toronto, Canada;3. Keenan Research Centre for Biomedical Science of St. Michael''s Hospital, Toronto;4. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto;5. Department of Nutritional Sciences, University of Toronto, Toronto, Canada;6. Division of Obstetrics and Gynecology, University of Toronto, Toronto, Canada;7. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada |
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| Abstract: | Measurement of diffusion and partitioning of solutes having molecular weights ranging 180–66000 in PVA gel membranes with various crosslinking degree were carried out. With increasing solute size or decreasing number of average molecular weight between crosslinks of the membranes, both the solute permeability and partition coefficient decreased. In spite of similar solute sizes, the more hydrophilic solute ribonuclease showed higher permeability and partition coefficient than the less hydrophilic α-lactalbumin, probably due to interaction with the hydrophilic PVA. The solute diffusion through swollen gel membrane was analyzed by the equation based on free volume theory. In this analysis equation, the partition coefficient, which is defined as the ratio of solute concentration in gel membrane standardized by water volume in the membrane to that in bulk solution, was introduced as the probability of a diffusing species finding a mesh with a volume of at least the solute size. The efficiency of the proposed analysis equation was confirmed by the experimental results of the effects of solute size and water volume fraction in the membrane. |
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