Asymmetric Synthesis of Novel Vicinal Amino Alcohols via Intramolecular Ketone-N-sulfinylimine Pinacol-Type Reductive Coupling Promoted by SmI2 |
| |
| Authors: | Yun-Hui Zhao Han-Wen Liu |
| |
| Institution: | Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan Province College Key Laboratory of QSAR/QSPR , Hunan University of Science and Technology , Xiangtan , China |
| |
| Abstract: | A novel intramolecular asymmetric ketone-N-sulfinylimine pinacol-type reductive coupling reaction induced by SmI2 was reported. A series of 1-amino-1,2,3,4-tetrahydronaphthalen-2-carbinols were obtained in moderate to good yields with excellent ee and high dr. Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] |
| |
| Keywords: | Asymmetric synthesis N-sulfinylimine samarium diiodide vicinal amino alcohol |
|
|
