Synthesis of New Tandospirone Analogues Carrying 1-(3-(Trifluoromethyl)phenyl)piperazine |
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| Authors: | Omer Tahir Gunkara Bilgesu Onur Sucu Muge Guleli |
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| Institution: | Faculty of Science and Arts , Yildiz Technical University , Istanbul , Turkey |
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| Abstract: | New tandospirone analogues containing a 1-3-(trifluoromethyl)phenyl]piperazine (TFMPP) moiety have been synthesized by hydroarylation reactions with Pd(OAc)2. The perhydroisoindole derivatives were obtained by the reaction of reduced starting material with aryl-(heteroaryl) iodides under the same conditions. Spiro-1,3-indandionolylpyrrolidine derivatives having an array of stereocenters are reported. |
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| Keywords: | Antidepressant drugs C-C coupling isoindoles spiro-1 3-indandionolylpyrrolidines tandospirone |
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