Efficient and Convenient Protocol for the Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles Using HClO4-SiO2 as a Heterogeneous Recyclable Catalyst |
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| Authors: | Ramu Tadikonda Mangarao Nakka Mahaboob Basha Gajula Srinuvasarao Rayavarapu Padma Rao Gollamudi |
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| Affiliation: | Department of Organic Chemistry and Foods, Drugs and Water , Andhra University , Visakhapatnam , India |
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| Abstract: | Silica-supported perchloric acid (HClO4-SiO2) was found to be a new, highly efficient, inexpensive, and reusable catalyst for a rapid and efficient synthesis of various 1,2,4-oxadiazoles with good to excellent yields under solvent-free conditions. The present methodology has been effectively utilized for the synthesis of oxolamine, an anti-inflammatory drug. |
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| Keywords: | Acid anhydrides amidoxime HCLO4-SiO2 1,2,4-oxadiazole reusable catalyst |
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