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C-S Bond-Forming Reactions of Barbiturylbromide with Isothiocarbamides in Aqueous Media |
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| Authors: | Madhuri M Sontakke Atul A Jichkar Chandrakant S Bhaskar Baliram N Berad |
| Institution: | 1. Department of Chemistry , RTM, Nagpur University , Nagpur , India;2. Department of Chemistry , Shri Mathuradas Mohota College of Science , Nagpur , India;3. Department of Chemistry , Arts, Commerce, and Science College , Koradi , India |
| Abstract: | The C-S cross coupling of pharmaceutically active barbituric acid derivatives has been achieved by the interaction of selective monobromobarbituric acid with thioureas in an aqueous medium. This method is applicable for simple thiourea as well as monosubstituted thioureas, and corresponding products are obtained in good yield. Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] |
| Keywords: | Aryl/H thiocarbamides C-S cross coupling of barbituryl isothiocarbamides monobromobarbituric acid |