Quality by Design Approach for Development of W/O Type Microemulsion-Based Transdermal Systems for Atenolol |
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| Authors: | Anjali Dhingani Jaydeep Patel Kevin Garala Mihir Raval Abhay Dharamsi |
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| Affiliation: | 1. Department of Pharmaceutics , Atmiya Institute of Pharmacy , Rajkot , Gujarat , India;2. Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India;3. Department of Pharmaceutics , Maliba Pharmacy College , Surat , Gujarat , India |
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| Abstract: | ![]()
The objective of the present investigation was to develop microemulsion-based transdermal systems of highly water soluble drug, Atenolol, by quality by design technique. Atenolol-loaded W/O microemulsions were optimized using D-optimal design with concentrations of oil, surfactants mixture, and water as independent variables, which was converted into microemulsion-based gel (MBG). The results of in vitro permeation of the optimized batch of Atenolol-loaded MBG revealed significant increase in permeability parameters as compared to its convention gel. All results suggested suitability of W/O type MEs as carriers for transdermal delivery of highly water soluble drug, Atenolol. |
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| Keywords: | Atenolol D-optimal design microemulsion principal component analysis quality by design thickening agents transdermal drug delivery |
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