Nickel-Catalyzed Reductive Alkylation of Halogenated Pyridines with Secondary Alkyl Bromides |
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| Authors: | Huiyan Liu Zhuye Liang Kunhua Lin |
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| Institution: | 1. Department of Chemistry , Shanghai University , Shanghai , China;2. College of Chemistry and Molecular Engineering , Zhengzhou University , Zhengzhou , China |
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| Abstract: | This article highlights Ni-catalyzed cross-electrophile coupling of halogenated pyridines with secondary alkyl bromides using zinc as the terminal reductant. With this protocol, we have successfully achieved different alkyl-substituted pyridines in moderate to excellent yields. |
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| Keywords: | Alkylation cross-coupling Ni-catalyzed pyridines zinc |
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