汉防己甲素全合成研究进展

汉防己甲素是防己科千金藤属植物粉防己中分离提取的双苄基异喹啉类生物碱，已作为临床药物用于抗风湿及阵痛、抗肺癌、抗矽肺。基于粉防己产量的限制及汉防己甲素的需求量增加，深入开展汉防己甲素的全合成研究势在必行。本文按照合成策略，对汉防己甲素的全合成方法进行了综述。

Research Progress on The Total Synthesis of Tetrandrine

Tetrandrine as dibenzyl isoquinoline alkaloid is isolated from Stephania tetrandra S.Moore,which has been used as a clinical drug for anti-rheumatic and labor pains,anti-lung cancer,anti-silicosis.Under the background of the underproduce of Stephania tetrandra and the increased demand for tetrandrine,intensive study of the total synthesis of tetrandrine is imperative.The developed total synthetic routes of tetrandrine have been presented in this review and we expect to be helpful for the further study of total synthesis of tetrandrine.