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Pyrazoles and Isoxazoles Based Sulfanilamide and Phenazone as Antimicrobial Agents: Synthesis and Biological Activity |
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| Authors: | Moustafa A. H. El-Sayed H. A. El Rayes S. M. Morsy H. A. Abd-allah S. H. Ismail H. F. Abd El-Aal M. M. |
| Affiliation: | 1.Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt ;2.Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt ;3.Higher Institution of Engineering & Modern Technology, Elmarg, Cairo, 13774, Egypt ;4.Department of Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, 44519, Egypt ; |
| Abstract: | New pyrazole and pyridine derivatives have been synthesized from sulfanilamide and phenazone via diazotization and coupling with a wide range of α-CH acids followed by heterocyclization with hydrazine derivative, hydroxylamine and cyanoacetamide. The antimicrobial tests of the products demonstrate high to moderate activity against Gram (?ve) bacteria and the tested fungi. No positive action of the products is observed against Gram (+ve) bacteria. |
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